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KMID : 0604520080340020129
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Journal of the Society of Cosmetic Scientists of Korea
2008 Volume.34 No. 2 p.129 ~ p.135
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The Study on the Potential Anti-aging Properties of Prunella vulgaris Extract In Vitro and In Vivo
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Hong Eun-Suk
Ahn Gi-Woong
Jo Byoung-Kee
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Abstract
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In this study, the potential anti-aging properties of Prunella vulgaris extract were investigated. According to our results, Prunella vulgaris extract increased collagen synthesis(74.7% at 250 ) and decreased on MMP-1 synthesis(90.2% at 200 ) and elastase activity(43.7% at 2.0%). Furthermore, it also showed free radical scavenging activity(76.9% at 2.0%) and reduced -induced cytoxicity(49.9% at 2.0%). A double-blind clinical study to investigate the effect of Prunella vulgaris extract on the skin’s surface was conducted with 22 healthy volunteers, aged 34 to 48 years. The volunteers applied a cream formula with 4.0% of Prunella vulgaris extract, or placebo cream, on each crow’s feet twice a day for 12 weeks. Skin wrinkles were evaluated with the naked eye and instrumental image analysis of silicone replicas, followed by statistical analysis. Twelve weeks after application of cream formula with 4.0% of Prunella vulgaris extract, we found significant improvement of facial wrinkle. Moreover, silicone replica analysis confirmed notable improvement in average of R2 and R3 at 12 weeks(p<0.05). These results demonstrate that Prunella vulgaris provides a remarkable and significant tensor and anti-wrinkle effect on the skin, which could be of great use in anti-aging skin care products.
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KEYWORD
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Prunella vulgaris, anti-aging, collagen, MMP-1, antioxidative activity
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